iMiDEV – Microfluidic Synthesizer
The ideal microfluidic environment to develop radiotracers
iMiDEV® offers a dedicated microfluidic environment designed to support radiotracer research and preclinical development, enabling efficient, reproducible, and low-volume synthesis directly on-site. By combining single-use microfluidic cartridges with advanced automation, the platform provides precise process control while minimizing reagent consumption and cross-contamination risks.
Microfluidics environment for R&D
- Designed for R&D and personalized medicine, enabling on-site production of patient-specific radiotracers
- Faster reaction rate even at lower temperature, with reduced reagent and precursor consumption
- Fully integrated single-use microfluidic cartridge minimizing dead volumes and preventing cross-contamination
With the rapid development of theranostics and personalized medicine, medical centers increasingly require access to a broader range of highly specific radiotracers, produced on-site and in small patient-specific quantities. Designed for R&D and preclinical phases, iMiDEV® addresses this need by providing a unique microfluidic environment optimized for radiotracer development and early-stage production.
Installed in a hotcell and directly connected to a cyclotron or an external radioisotope source, iMiDEV® relies on a fully integrated, single-use microfluidic cartridge. This cartridge incorporates valves, channels, reaction chambers and SPE units in a completely closed system, minimizing dead volumes and eliminating cross-contamination risks. Microfluidic operation enables faster reaction rates, even at lower temperatures, while significantly reducing reagent and precursor consumption.
Automation for Reproducible Synthesis
- Manuel or fully automated synthesis, including HPLC purification
- Dedicated automation scripts for fast, reliable recipe development with full process control
- Comprehensive synthesis reports collecting date from all actuators and sensors
iMiDEV® can be operated either manually or in a fully automated mode, including HPLC purification. Automated syntheses are driven by dedicated scripts built from validated functions, allowing new synthesis recipes to be created quickly and reliably. Throughout the entire process, all parameters are monitored and controlled, ensuring reproducibility and precise process control.
Each synthesis generates a comprehensive report, collecting data from all actuators and sensors. This detailed traceability enables rapid troubleshooting, efficient optimization, and smooth development cycles—key advantages for research environments and method development laboratories.
Versatiliy and Seamless Transfer Toward Clinical Production
- Proven production of a wide range of ¹¹C-, ¹⁸F- and ⁶⁸Ga-labeled tracers
- Continuity across development platforms, from iMiDEV to iMiLAB or other platforms
- Accelerating the path from development to routine production
Based on its flexible microfluidic architecture, iMiDEV® has already been used successfully to produce a wide range of ¹¹C-, ¹⁸F- and ⁶⁸Ga-labeled tracers, including clinically relevant and emerging compounds. Once a process is established, transfer to other iMiDEV systems or to iMiLAB, the GMP-compliant radiochemistry production platform, is straightforward.
This continuity enables rapid scale-up toward clinical practice, making iMiDEV® an ideal bridge between radiotracer research, preclinical validation and clinical production.
How Radiotracers Synthesis Works on iMiDEV®
Radiotracers Successfully Synthesized with iMiDEV®
| 11C – Labeled Tracers | [11C]flumazenil, [11C]L-deprenyl, [11C]methionine, [11C]choline |
|---|---|
| 18F – Labeled Tracers | [18F]DPA-714, [18F]LBT-999, [18F]NaF, [18F]fallypride, [18F]AIF-PSMA-11 |
| 68Ga – Labeled Tracers | [68Ga]Ga-FAPI-46, [68Ga]Ga-PSMA-11, [68Ga]Ga-DOTA-TOC, [68Ga]Ga-citrate |